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SUBSYS Medication Information

For SUBSYS® Prescribers: Access information about SUBSYS indications, dosage information, and safety information for your patients.  
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SUBSYS Indications

SUBSYS is first and only fentanyl sublingual spray for breakthrough cancer pain. SUBSYS helps manage the intense and rapid flare-ups of pain that cancer patients often experience by providing relief in as little as 5 minutes.




Spray the medication in your mouth underneath the tongue. Hold the medication under your tongue for 30 to 60 seconds. Do not spit out the medication or rinse out your mouth after using the spray. Do not take more than 2 doses for each episode of breakthrough cancer pain.


Safety Information

Do not use SUBSYS for a condition for which it was not prescribed. Do not give SUBSYS to other people, even if they have the same symptoms you have. If you would like more information about SUBSYS, talk with your provider or ask our pharmacists. 


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I just wanted to take the time to tell you how wonderful the staff at Avella is! They are always so quick to respond and so helpful. They are all knowledgeable and always able to get us the information we need. We recently had a patient that was denied hepatitis C treatment and they were quick to start the appeal process and get us an appeal letter that only needed to be signed by the physician. We all really appreciate all that Avella does!
Provider, Denver, CO