PROBUPHINE is indicated for the maintenance treatment of opioid dependence in patients who have achieved and sustained prolonged clinical stability on low-to-moderate doses of a buprenorphine-containing product.
Each dose consists of four PROBUPHINE implants inserted subdermally in the upper arm for six months of treatment and removed by the end of the sixth month. PROBUPHINE must be inserted and removed by trained providers.
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PROBUPHINE is not appropriate for new entrants to treatment and patients who have not achieved and sustained prolonged clinical stability. PROBUPHINE is available only through the PROBUPHINE REMS Program.
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